PEP (Post-Exposure Prophylaxis) is a 28-day course of emergency HIV medication. It must be started within 72 hours of a high-risk exposure, but the sooner you start it, the more effective it is. In Northern Ireland, it is free through HSCNI.

🚨 Where to Go Right Now

Your route depends entirely on the time of day. Do not wait for an appointment slot.

Time / DayWhere to GoWhat to Expect
Weekday (Daytime)Local HSC Trust GUM ClinicCall the Belfast GUM (028 9615 2111) or your nearest clinic immediately. They will fast-track you.
Evening / Weekend / Bank HolidayHospital A&E (Emergency Department)Go to the Royal Victoria Hospital A&E in Belfast, or your nearest hospital A&E. Prepare to wait in triage.
Unsure where to go?Call GP Out of HoursIf you are unsure, check NI Direct or call your local GP Out of Hours service. (Do not rely on NHS 111 for PEP routing in NI).

Do not go to your GP. General Practices do not stock PEP. They will simply redirect you to A&E, wasting critical hours in your 72-hour window.

🗣️ Navigating A&E Triage

A&E is a high-pressure, general emergency environment. To ensure you are triaged correctly, use clear language.

  • Use the terminology: Say, "I need an emergency assessment for PEPSE" (Post-Exposure Prophylaxis following Sexual Exposure).
  • State the timeline: "The exposure was [X] hours ago. I know I have a 72-hour window."
  • Be direct about the exposure: State exactly what happened (e.g., receptive anal sex without a condom).

The Starter Pack: A&E will often only give you a 3-to-5-day "starter pack" of PEP. You must attend a GUM clinic on the next working day. This is mandatory to get the rest of your medication and to complete vital follow-up blood tests.

💊 The Medication: What to Expect

The standard UK PEP regimen usually consists of Truvada (or a generic equivalent) taken alongside either raltegravir or dolutegravir.

  • It is a strict regimen: PEP is a mandatory 28-day course. You cannot miss doses.
  • Side effects are manageable: You may experience nausea, fatigue, or diarrhea. The clinic will often prescribe anti-sickness medication alongside your PEP.
  • Do not stop: Never stop taking PEP without speaking to a doctor first.

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